Author's response to reviews Title: The Association Between Celiac Disease and Eosinophilic Esophagitis in Children and Adults Authors:

2013 Update on Celiac Disease and Eosinophilic Esophagitis

Celiac disease is a chronic, immune-mediated disorder, characterized by small intestinal inflammation and villous atrophy after the ingestion of gluten by genetically susceptible individuals. Several extraintestinal manifestations have been associated to celiac disease. Eosinophilic esophagitis is a primary disorder of the esophagus characterized by upper gastrointestinal symptoms, absence of g...

Author's response to reviews Title: Importance of Duodenal Bulb Biopsies in Children for Diagnosis of Celiac Disease in Clinical Practice Authors:

Increased incidence of eosinophilic esophagitis in children and adults with celiac disease.

GOALS AND BACKGROUND Case series have suggested an association between eosinophilic esophagitis (EoE) and celiac disease (CD) in children. We analyzed a cohort of patients with CD to confirm this association in children, and determine whether it extends into adulthood. METHODS A database of patients with CD was reviewed to determine the number of patients with comorbid diagnoses of EoE. Histo...

Adherence to Celiac Disease and Eosinophilic Esophagitis Biopsy Guidelines Is Poor in Children.

OBJECTIVES Celiac disease (CD) and eosinophilic esophagitis (EoE) are underdiagnosed gastrointestinal conditions, which adversely affect children's health. Previous studies have shown that diagnostic guidelines for CD are not consistently followed in adults. The aims of the present study are to assess the frequency with which endoscopists comply with diagnostic guidelines for CD and EoE in chil...

The association between celiac disease and eosinophilic esophagitis in children and adults

BACKGROUND An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases. METHODS All patients in a large Canadian city diagnosed with EoE or CD over a five-year period were identified. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) wer...